Oxycodone 80mg – Wellnessmedicalshop Reference

Generic Name: Oxycodone Hydrochloride
Strength: 80mg
Dosage Form: Oral tablet (commonly extended-release)
Pharmacological Class: Opioid Analgesic

Indications

Oxycodone 80mg is indicated for the management of severe, persistent pain requiring continuous, around-the-clock opioid therapy and for which alternative treatments are inadequate. Common clinical uses include:

Cancer-related pain

Post-surgical pain (in select cases)

Severe musculoskeletal or neuropathic pain not controlled by non-opioid or weaker opioid analgesics

Mechanism of Action

Oxycodone is a full opioid agonist that primarily acts on the mu-opioid receptors in the central nervous system (CNS). This interaction alters the perception of pain and emotional response to pain, resulting in analgesia, sedation, and euphoria.

Pharmacokinetics

Absorption: Well absorbed orally; extended-release formulation provides prolonged plasma concentrations.

Onset of Action: ~1 hour (oral)

Duration of Action: 8–12 hours (extended-release)

Metabolism: Hepatic via CYP3A4 and CYP2D6 pathways

Elimination: Primarily renal

Contraindications

Significant respiratory depression

Acute or severe bronchial asthma in unmonitored settings

Known hypersensitivity to oxycodone or other opioids

Paralytic ileus

Warnings & Precautions

Addiction, Abuse, and Misuse: High risk, even at recommended doses.

Life-Threatening Respiratory Depression: Especially during initiation or dose escalation.

Accidental Ingestion: Particularly dangerous in children.

Neonatal Opioid Withdrawal Syndrome: Possible if used during pregnancy.

Concomitant Use with CNS Depressants (e.g., benzodiazepines, alcohol): May result in profound sedation, respiratory depression, coma, or death.

Adverse Reactions

Common: Constipation, nausea, vomiting, dizziness, sedation, pruritus

Serious: Respiratory depression, hypotension, seizures, dependence, overdose

Dosage & Administration

Dose must be individualized based on patient’s prior opioid use, pain severity, and clinical response.

Extended-release tablets must be swallowed whole; crushing, chewing, or dissolving may cause rapid release of oxycodone and potentially fatal overdose.

Overdose Management

Symptoms: Severe respiratory depression, pinpoint pupils, extreme somnolence, hypotension, circulatory collapse
Treatment: Immediate medical attention, airway support, and administration of naloxone as an opioid antagonist