Phentermine.
Phentermine is a prescription appetite suppressant used to aid weight loss in adults who are overweight or obese. It is usually prescribed along with a reduced-calorie diet, exercise, and behavioral changes.
How it Works
Phentermine is a central nervous system stimulant related to amphetamines. It works by:
- Increasing the release of norepinephrine in the brain
- Suppressing appetite, making it easier to reduce calorie intake
- Slightly increasing metabolism in some patients
Common Medical Uses
- Short-term weight loss (usually prescribed for a few weeks)
- Part of a comprehensive weight management program for patients with BMI ≥ 30, or BMI ≥ 27 with weight-related conditions such as hypertension, diabetes, or high cholesterol
Benefits
- Helps reduce appetite and food intake
- Can support modest weight loss when combined with diet and exercise
- May improve blood pressure, cholesterol, and blood sugar levels in overweight patients
Possible Side Effects
- Increased heart rate, palpitations
- Elevated blood pressure
- Insomnia, restlessness, anxiety
- Dry mouth, constipation
- Rare: pulmonary hypertension or heart valve issues (mostly with long-term use or combination therapy)
Important Precautions
- Short-term use: Typically prescribed for 12 weeks or less due to tolerance and side effect risk
- Cardiovascular risk: Not recommended for people with heart disease, uncontrolled hypertension, or history of stroke
- Drug interactions: Avoid combining with other stimulants, MAO inhibitors, or certain antidepressants
- Pregnancy & breastfeeding: Should not be used
Summary
Phentermine is a short-term prescription appetite suppressant that helps promote weight loss when combined with diet and exercise. It can be effective but carries stimulant-related side effects and is not suitable for everyone, particularly those with cardiovascular conditions.
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