Dilaudid (Hydromorphone Hydrochloride)

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Dilaudid is a potent opioid analgesic medication containing hydromorphone hydrochloride. It is used for the management of moderate to severe pain in patients who require continuous, around-the-clock opioid treatment and for whom alternative options are inadequate.

Dosage Forms & Strengths:

Tablets: 2 mg, 4 mg, 8 mg

Oral Solution: 1 mg/mL

Injectable Solution: Various strengths (typically 1 mg/mL, 2 mg/mL, 4 mg/mL, 10 mg/mL)

Suppositories: 3 mg

Pharmacology:

Active Ingredient: Hydromorphone Hydrochloride

Class: Opioid agonist

Mechanism: Binds to mu-opioid receptors in the CNS, altering the perception and response to pain.

Onset: Rapid (especially injection forms)

Duration: Short-acting (generally 4–6 hours)

Indications:

Severe acute or chronic pain

Post-surgical pain management

Pain in cancer or palliative care when other opioids are insufficient

Special Considerations:

High risk of addiction, abuse, and misuse.

May cause respiratory depression, hypotension, and sedation.

Contraindicated in patients with severe respiratory depression, acute asthma, or paralytic ileus.

Careful dose titration required, especially when converting from other opioids.

Common Side Effects:

Drowsiness, dizziness

Constipation, nausea, vomiting

Sweating, itching

Respiratory depression (serious)

Storage:

Store at controlled room temperature (20°C–25°C).

Keep out of reach of children.

Classified as a Schedule II controlled substance.